Frequently Asked Questions
There are over 7,000 known peptides that occur naturally in the human body. As of February 2024, the FDA has approved more than 100 peptide-based drugs for various medical uses. According to the National Library of Medicine, peptides and oligonucleotides represented 16% of the newly approved FDA drugs in 2023, an increase from 14% in 2022. As the popularity and applications of peptides continue to grow, we can expect an increase in FDA approvals.
No, not all of BUFF’s approaches use injectables. While injectables are often the most effective delivery method due to the potential degradation of peptides through other methods, there are alternative options available. Many peptides can also be administered effectively via oral pills, troches, or nasal sprays. During your consultation, your advisor and prescriber will review all available delivery methods and recommend the most effective or suitable option based on your individual needs.
Injections can be administered either intramuscularly or subcutaneously. During your consultation, we’ll discuss proper injection techniques and sites to help minimize discomfort. BUFF’s consultants, who are also experienced self-biohackers, leverage their expertise to reduce or eliminate pain associated with injections.
The cost of peptides can vary based on several factors, including the dose, length of treatment, cycle duration, choice of peptide (as many peptides can achieve similar effects), and whether you choose to stack multiple peptides. For example, peptides such as Semaglutide, Tirzepatide, and Retatrutide are commonly used for weight loss. Your consultant will work with you to create a tailored protocol that fits your budget and helps you achieve your desired goals.
Peptides were first discovered in 1901 when Emil Fischer and Ernest Fourneau synthesized the first synthetic peptide.
There are over 7,000 known peptides that occur naturally in the human body. As of February 2024, the FDA has approved more than 100 peptide-based drugs for various medical uses. According to the National Library of Medicine, peptides and oligonucleotides represented 16% of the newly approved FDA drugs in 2023, an increase from 14% in 2022. As the popularity and applications of peptides continue to grow, we can expect an increase in FDA approvals.
In some cases, insurance may cover all or part of the cost of peptide prescriptions, depending on your specific insurance plan and the therapy in question. It’s best to check with your insurance provider to understand your coverage details and potential out-of-pocket costs.
Administering testosterone typically involves a few different methods, each with its own process. Here’s an overview:
1. Injections:
Intramuscular: Testosterone can be injected directly into a muscle, usually every one to two weeks. Common sites include the gluteus or thigh muscles.
Subcutaneous: Some prefer to inject testosterone under the skin, often in the abdomen or thigh, which can be done more frequently (e.g., weekly).
2. Topical Gels:
Testosterone gel is applied to clean, dry skin, usually on the shoulders, upper arms, or abdomen. It needs to dry before dressing and should not be washed off for a few hours.
3. Patches:
Transdermal patches are applied to the skin and deliver testosterone over a 24-hour period. They are typically worn on the upper body or arm.
4. Pellets:
Testosterone pellets can be implanted under the skin, usually in the hip area. They release testosterone slowly and typically last for several months.
5. Oral Tablets:
Though less common, there are oral formulations available. These may have specific administration guidelines to minimize liver impact.
Regardless of the method, it’s crucial to follow a healthcare provider’s guidance for dosage and administration. Regular monitoring of hormone levels and overall health is also important. Our healthcare provider will consult with you on any specific questions or concerns.
All methods of testosterone administration can have side effects, but they may vary in severity and type. Here’s a breakdown:
Injections:
Intramuscular: Possible pain at the injection site, mood swings, and fluctuations in hormone levels can lead to side effects like acne or increased aggression. Maintaining proper medicinal doses of testosterone can help reduce the risks and side effects associated with therapy
Subcutaneous: Similar side effects as intramuscular, but also potential for irritation at the injection site.
Topical Gels:
Skin irritation or rash is common. There’s also a risk of transferring testosterone to others through skin contact, which can lead to unintended effects in others (especially women and children).
Patches:
Skin irritation or allergic reactions can occur. Fluctuations in hormone levels can still happen, leading to side effects like mood changes.
Pellets:
Potential for pain, swelling, or infection at the implantation site, as well as possible pellet extrusion or migration. Hormonal side effects like mood swings and changes in libido can also occur. Fluid retention such as swelling in the legs or other areas. Sleep disturbances such as insomnia or sleep apnea
Oral Tablets:
Oral testosterone can have more significant liver-related side effects and may also cause gastrointestinal issues. It can also lead to elevated cholesterol levels.
It’s essential to discuss potential side effects and monitoring with a healthcare provider to manage any risks effectively.
Our provider is the best resource for risk reduction strategies when using testosterone. We offer personalized advice based on your medical history, current health status, and the method of administration you’re considering. Here are some general approaches we might suggest:
- Regular Monitoring: Routine blood tests to check hormone levels, liver function, and other relevant parameters can help catch any issues early.
- Dosage Management: Starting with a lower dose and adjusting as needed can help minimize side effects.
- Injection Technique: If you’re using injections, proper technique and hygiene can reduce the risk of infection or irritation.
- Skin Care: For topical methods, applying the gel or patch to clean, dry skin and allowing it to dry before dressing can minimize skin reactions.